THE IMPORTANCE OF MARKERS OF OSTEOLYSIS AND OSTEOGENESIS IN THE PATHOGENESIS OF CEPHALOHEMATOMA IN NEWBORNS

Background.Of particular importance in the repair process for cephalohematomas is the pathological remodeling of the bones of the cranial vault.Local changes in the bones of the skull are accompanied by the processes of osteolysis and osteogenesis and have uncertain dynamics.Changes in the state of bone tissue in cephalohematomas can be monitored b

Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs.Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field a